Incredible Hulk (1962) #374
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Caught in a gamma bomb explosion while trying to save the life of a teenager, Dr. Bruce Banner was transformed into the incredibly powerful creature called the Hulk. An all too often misunderstood hero, the angrier the Hulk gets, the stronger the Hulk gets.
After the Fantastic Four stopped the Skrulls' attempted invasion of Earth, Skrull Emperor Dorrek invested vast resources into creating a superbeing of his own.
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.