Incredible Hulk (1962) #250
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Caught in a gamma bomb explosion while trying to save the life of a teenager, Dr. Bruce Banner was transformed into the incredibly powerful creature called the Hulk. An all too often misunderstood hero, the angrier the Hulk gets, the stronger the Hulk gets.
When Zenn-La was threatened by the world-devouring entity known as Galactus, Norrin Radd stood up for his home planet and offered to work for Galactus, finding him new planets to eat, in exchange for saving his own. Years later, the Surfer has protected Earth and many other planets, becoming one of the greatest heroes in the universe.
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.