Avengers (1963) #240
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Earth's Mightiest Heroes joined forces to take on threats that were too big for any one hero to tackle. With a roster that has included Captain America, Iron Man, Ant-Man, Hulk, Thor, Wasp and dozens more over the years, the Avengers have come to be regarded as Earth's No. 1 team.
Seriously wounded, young lawyer Jennifer Walters was given a blood transfusion by her cousin Bruce Banner. Usually in better control of her powers and temper than the Hulk, She-Hulk has been a high profile New York lawyer as well as an upstanding member of both the Avengers and Fantastic Four.
When young Jessica Drew suffered uranium poisoning in 1931, her father was forced to inject her with his untested spider serum and seal her in a genetic accelerator.