The Amazing Spider-Man (1963) #403
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Mary Jane Watson was the guiding light in Peter Parker's life, and their love had overcome countless obstacles.
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
Edward Whelan was found roaming the streets of New York by Baron Helmut Zemo, who subjected Whelan to Zemo's genetic experiments, which granted him superhuman strength, but, in the process of the mutation, he manifested a rat-like physical appearance, and was called Vermin.
Malcolm McBride was transformed into Carrion after coming into contact with a Carrion "virus" left behind by the High Evolutionary of the Cult of the Jackal in an effort to discredit the actions of the first Carrion.