Amazing Spider-Man (1999) #667
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Characters
Caught in a gamma bomb explosion while trying to save the life of a teenager, Dr. Bruce Banner was transformed into the incredibly powerful creature called the Hulk. An all too often misunderstood hero, the angrier the Hulk gets, the stronger the Hulk gets.
Mary Jane Watson was the guiding light in Peter Parker's life, and their love had overcome countless obstacles.
Shang-Chi is the son of an internationally-renowned and powerful criminal mastermind whose childhood was a lonely one, full of constant training in rigorous mental and martial arts, with only limited contact with his parents.
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
When young Jessica Drew suffered uranium poisoning in 1931, her father was forced to inject her with his untested spider serum and seal her in a genetic accelerator.
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.
One of Spider-Man's oldest enemies, Mac Gargan has recently abandoned his Scorpion suit and identity and bonded with the alien symbiote that had previously been hosted by Peter Parker and Eddie Brock, becoming the new Venom.