Amazing Spider-Man (1999) #666
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Mary Jane Watson was the guiding light in Peter Parker's life, and their love had overcome countless obstacles.
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
When young Jessica Drew suffered uranium poisoning in 1931, her father was forced to inject her with his untested spider serum and seal her in a genetic accelerator.
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.