Ultimate Fantastic Four/X-Men (2006) #1
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After fourteen-year-old Kitty Pryde's mutant powers emerged, causing terrifying incidents where she uncontrollably phased out of the family apartment in to moving traffic andsewers, her mother Theresa contacted Professor Xavier.
When the time came for Reed Richards to demonstrate his teleportation device, his old friend Ben Grimm was invited to observe, but the device malfunctioned and Ben woke up in Mexico City, transformed into a rocky, brutish Thing.
Decades after participating in military airdrops with Captain America during WWII, James Howlett was abducted and experimented upon by a covert government unit, who bonded unbreakable adamantium to his skeleton, implanted three claws in each arm, dubbed him Weapon X and supposedly programmed him to kill any human he came into contact with.