Amazing Spider-Man (1999) #648
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Earth's Mightiest Heroes joined forces to take on threats that were too big for any one hero to tackle. With a roster that has included Captain America, Iron Man, Ant-Man, Hulk, Thor, Wasp and dozens more over the years, the Avengers have come to be regarded as Earth's No. 1 team.
After being exposed to cosmic rays, Reed Richards, Susan Storm, Ben Grimm and Johnny Storm found they had amazing new powers. Reed Richards found he has the ability to stretch his body in any way he wanted, while Susan Storm can turn herself, objects and other people invisible. Ben Grimm transformed into a rocky, super-strong behemoth and Johnny Storm has the ability to set himself on fire. Dubbed the Fantastic Four, Mr. Fantastic, Invisible Woman, Thing and the Human Torch are Marvel's First Family.
Mary Jane Watson was the guiding light in Peter Parker's life, and their love had overcome countless obstacles.
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
One of Spider-Man's oldest enemies, Mac Gargan has recently abandoned his Scorpion suit and identity and bonded with the alien symbiote that had previously been hosted by Peter Parker and Eddie Brock, becoming the new Venom.
Adrian Toomes is a former electronics engineer who employs a special harness of his own design that allows him to fly and endows him with enhanced strength.