Amazing Spider-Man (1999) #603
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Mary Jane Watson was the guiding light in Peter Parker's life, and their love had overcome countless obstacles.
Mary Jane Watson always wanted to be an actress, but all the roles seemed to go to mutants, until her former high school friend, and world famous performer, Peter Parker asked her to play his love interest in his newest movie, upon the release of which made her America's sweetheart and one of the only human movies stars able to launch her own solo projects.
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.