Amazing Spider-Man (1999) #596
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Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
One of Spider-Man's oldest enemies, Mac Gargan has recently abandoned his Scorpion suit and identity and bonded with the alien symbiote that had previously been hosted by Peter Parker and Eddie Brock, becoming the new Venom.