Ultimate X-Men (2001) #91
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Peter’s relatively normal life changed abruptly during a school trip to Osborn Industries, Inc, where the company had been working on a super soldier serum, the Oz Compound; a spider exposed to it escaped and bit Peter before it was destroyed.
Ororo Munroe was raised in Morocco, learning English from American films, and after her family was murdered she fled to America, stealing cars in Harlem before relocating to Texas.
Decades after participating in military airdrops with Captain America during WWII, James Howlett was abducted and experimented upon by a covert government unit, who bonded unbreakable adamantium to his skeleton, implanted three claws in each arm, dubbed him Weapon X and supposedly programmed him to kill any human he came into contact with.