Defenders (1972) #114
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Characters
Caught in a gamma bomb explosion while trying to save the life of a teenager, Dr. Bruce Banner was transformed into the incredibly powerful creature called the Hulk. An all too often misunderstood hero, the angrier the Hulk gets, the stronger the Hulk gets.
When Zenn-La was threatened by the world-devouring entity known as Galactus, Norrin Radd stood up for his home planet and offered to work for Galactus, finding him new planets to eat, in exchange for saving his own. Years later, the Surfer has protected Earth and many other planets, becoming one of the greatest heroes in the universe.
Valkyrie (Samantha Parrington)
Amora magically transformed Samantha Parrington into a raging, man-hating facsimile of the Asgardian warrior goddess Brunnhilde the Valkyrie, whose form and might Amora could replicate at will, having trapped Brunnhilde's soul in a mystical crystal centuries earlier.
The metal monstrosity called Ultron created the synthetic humanoid known as the Vision from the remains of the original android Human Torch of the 1940s to serve as a vehicle of vengeance against the Avengers.