Marvel Two-in-One (1974) #56
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Characters
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.
Thundra was quite possibly her world's greatest female specimens, and as she won countless battles against the men, she was revered as the Sisterhood's greatest hero.
Despondent and hopeless after it was discovered that she was not, in fact, Spider-Woman, Mary MacPherran encountered Doctor Doom, who offered her a chance to become superpowered in exchange for joining his army, to which Mary readily agreed, and Doom transformed her into Titania.