New X-Men (2004) #10
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Prior to enrolling at the Xavier Institute, Noriko Ashida lived on the street and was reliant on illegally obtained prescription drugs to reduce her highly accelerated mutant brain functions to a manageable rate.
Laurie Collins began to involuntarily manipulate anyone around her once her genetic mutation manifested, unable to control its effects.
When his genetic mutation manifested, Kevin Ford accidentally killed his father with his lethal and uncontrollable touch, after which he was recruited as a student at the Xavier Institute.
Born with super-human senses and the power to heal from almost any wound, Wolverine was captured by a secret Canadian organization and given an unbreakable skeleton and claws. Treated like an animal, it took years for him to control himself. Now, he's a premiere member of both the X-Men and the Avengers.