The Mighty Avengers (2007) #6
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Earth's Mightiest Heroes joined forces to take on threats that were too big for any one hero to tackle. With a roster that has included Captain America, Iron Man, Ant-Man, Hulk, Thor, Wasp and dozens more over the years, the Avengers have come to be regarded as Earth's No. 1 team.
Wounded, captured and forced to build a weapon by his enemies, billionaire industrialist Tony Stark instead created an advanced suit of armor to save his life and escape captivity. Now with a new outlook on life, Tony uses his money and intelligence to make the world a safer, better place as Iron Man.
Empowered by the enigmatic Professor's secret formula, high school student Robert Reynolds became a superhuman.
When young Jessica Drew suffered uranium poisoning in 1931, her father was forced to inject her with his untested spider serum and seal her in a genetic accelerator.
Arguably the greatest and certainly the most horrific creation of scientific genius Dr. Henry Pym, Ultron is a criminally insane rogue sentient robot dedicated to conquest and the extermination of humanity.
When Janet Van Dyne's father died, she convinced her father's associate Hank Pym to give her a supply of "Pym particles"; Pym also subjected her to a procedure which granted her the ability to, upon shrinking, grow wings and fire blasts of energy, which she called her "wasp's stings."
Simon Williams agreed to undergo an experiment to give him superhuman powers, and Baron Zemo gave him the costumed guise of Wonder Man, warning Simon that he would die without further treatments from Zemo in order to ensure his loyalty, but Simon betrayed Zemo to the Avengers and ultimately joined their ranks.