New Avengers (2004) #34
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Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
When young Jessica Drew suffered uranium poisoning in 1931, her father was forced to inject her with his untested spider serum and seal her in a genetic accelerator.
Born with super-human senses and the power to heal from almost any wound, Wolverine was captured by a secret Canadian organization and given an unbreakable skeleton and claws. Treated like an animal, it took years for him to control himself. Now, he's a premiere member of both the X-Men and the Avengers.