Fantastic Four (1998) #22
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Characters
After being exposed to cosmic rays, Reed Richards, Susan Storm, Ben Grimm and Johnny Storm found they had amazing new powers. Reed Richards found he has the ability to stretch his body in any way he wanted, while Susan Storm can turn herself, objects and other people invisible. Ben Grimm transformed into a rocky, super-strong behemoth and Johnny Storm has the ability to set himself on fire. Dubbed the Fantastic Four, Mr. Fantastic, Invisible Woman, Thing and the Human Torch are Marvel's First Family.
Seriously wounded, young lawyer Jennifer Walters was given a blood transfusion by her cousin Bruce Banner. Usually in better control of her powers and temper than the Hulk, She-Hulk has been a high profile New York lawyer as well as an upstanding member of both the Avengers and Fantastic Four.
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.
Despondent and hopeless after it was discovered that she was not, in fact, Spider-Woman, Mary MacPherran encountered Doctor Doom, who offered her a chance to become superpowered in exchange for joining his army, to which Mary readily agreed, and Doom transformed her into Titania.