Uncanny X-Men (1981) #363
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British-born Mortimer Toynbee, abandoned by his parents so early in childhood that he cannot remember them, was placed in an orphanage where the other children, who regarded him as a freak due to his ugliness, his unusual physique and his leaping ability, continually tormented him.
Born with super-human senses and the power to heal from almost any wound, Wolverine was captured by a secret Canadian organization and given an unbreakable skeleton and claws. Treated like an animal, it took years for him to control himself. Now, he's a premiere member of both the X-Men and the Avengers.