Uncanny X-Men (1981) #348
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Characters
Bitten by a radioactive spider, high school student Peter Parker gained the speed, strength and powers of a spider. Adopting the name Spider-Man, Peter hoped to start a career using his new abilities. Taught that with great power comes great responsibility, Spidey has vowed to use his powers to help people.
Feared and hated by humans because they're different, the X-Men are heroic mutants, individuals born with special powers who've sworn to use their gifts to protect mutants as well as humans.