Uncanny X-Men (1981) #191
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Adam Warlock is an artificially created human who was born in a cocoon at a scientific complex called The Beehive.
Ororo Monroe is the descendant of an ancient line of African priestesses, all of whom have white hair, blue eyes, and the potential to wield magic.
Growing up in a wealthy Brazilian family, Roberto da Costa was forging a career as a skilled soccer player until his mutant nature manifested during a match.
The metal monstrosity called Ultron created the synthetic humanoid known as the Vision from the remains of the original android Human Torch of the 1940s to serve as a vehicle of vengeance against the Avengers.
When Janet Van Dyne's father died, she convinced her father's associate Hank Pym to give her a supply of "Pym particles"; Pym also subjected her to a procedure which granted her the ability to, upon shrinking, grow wings and fire blasts of energy, which she called her "wasp's stings."