Fantastic Four (1961) #395
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After being exposed to cosmic rays, Reed Richards, Susan Storm, Ben Grimm and Johnny Storm found they had amazing new powers. Reed Richards found he has the ability to stretch his body in any way he wanted, while Susan Storm can turn herself, objects and other people invisible. Ben Grimm transformed into a rocky, super-strong behemoth and Johnny Storm has the ability to set himself on fire. Dubbed the Fantastic Four, Mr. Fantastic, Invisible Woman, Thing and the Human Torch are Marvel's First Family.
Seriously wounded, young lawyer Jennifer Walters was given a blood transfusion by her cousin Bruce Banner. Usually in better control of her powers and temper than the Hulk, She-Hulk has been a high profile New York lawyer as well as an upstanding member of both the Avengers and Fantastic Four.
The radiation that mutated Reed Richards, Sue Storm and Johnny Storm into superhuman beings had also mutated Ben Grimm, transforming him into a grotesque, rock-hided strongman dubbed the Thing.
Born with super-human senses and the power to heal from almost any wound, Wolverine was captured by a secret Canadian organization and given an unbreakable skeleton and claws. Treated like an animal, it took years for him to control himself. Now, he's a premiere member of both the X-Men and the Avengers.